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The in vivo imaging system must be capable of the following;
• Highly sensitive 2D fluorescence and bioluminescence in vivo imaging. 4 magnification settings, the ability to image 10 mice simultaneously (with temperature and anaesthesia control), and computer-regulated narrow band-pass excitation filters covering the range of 300-900 nm.
• 3D-tomographic reconstruction for both bioluminescence and fluorescence using real CT data to create a non-uniform light absorption/scattering map. The 3D reconstruction to correct for non-uniform light absorption/scattering by different organs/tissue allowing for non-invasive and much more precise assessment of heart, GI tract and CNS infections.
• The X-ray CT facility must be able to combines scan times down to 5 seconds for total body mouse imaging, ultra-low X-ray dosage (down to 2 mGy), and an ability to image 4 mice simultaneously.
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The in vivo imaging system should be capable of the following:
• Highly sensitive 2D fluorescence and bioluminescence in vivo imaging. 4 Fields of View, the ability to image optically 10 mice simultaneously (with temperature and anaesthesia control), using narrow band-pass excitation filters covering the range of (420-740nm).
• 3D-tomographic reconstruction for both bioluminescence and fluorescence using real CT data to create a co registered image. Retrospective CT gating to allow precise assessment of cardiac and respiratory gating. The system should also be able to carry out GI tract and CNS infection imaging.
• The X-ray CT facility must be able to carry out total body mouse imaging, using low X-ray dosage.